The No. 1-ranked Sinner, the defending champion in singles at Flushing Meadows, was supposed to compete in mixed doubles with Katerina Siniakova.

Jannik Sinner has withdrawn from the US Open mixed doubles event after retiring from the Cincinnati Open due to illness. Danielle Collins and Christian Harrison will replace Sinner and Katerina Siniakova in the draw.

Jannik Sinner and Katerina Siniakova have withdrawn from the US Open mixed doubles after Sinner's illness during the Cincinnati Open final against Car