The 49ers moved to 4-2 with the win, and running back Christian McCaffrey did it all for Kyle Shanahan's team. McCaffrey had 24 carries for 129 yards and a pair of touchdowns and he also led the team with seven receptions for 72 yards on eight targets.

NFL Week 8 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and Houston Texans.

NFL Hall of Famer Patrick Willis traded the gridiron for a dining room as he teamed up with Pepsi and the San Francisco 49ers to provide free meals to fans and residents at Delancey Street Restaurant.

The Atlanta Falcons and San Francisco 49ers (-1.5, 47) meet in a key matchup of NFC contenders in NFL Week 7 'Sunday Night Football' at 8:20 p.m. ET from Levi's Stadium in Santa Clara, Calif. The Falcons (3-2) are second in the NFC South,

Who is 'Matt Jones'? 49ers' QB depth chart has NFL fans confused originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. Some words sound very similar. Or in this case, names, like Matt and Mac.

The San Francisco 49ers could use some defensive reinforcements given the injuries they are dealing with this season, and they are reportedly interested in a handful of New York Jets players ahead of the Nov.

The 49ers are starting backup quarterback Mac Jones, who will be making his fifth appearance in seven games in place of Brock Purdy. The Niners are getting somewhat healthier with the return of star tight end George Kittle,

While the loss already had to sting by itself, San Francisco's three-time All-Pro left tackle Trent Williams may find himself having even more disdain for the Week 6 loss. With 5:52 remaining in the fourth quarter and the 49ers trailing 27-19, Williams got tangled up with Tampa Bay safety Tykee Smith.