Philadelphia Eagles defensive coordinator Vic Fangio explained the challenges presented by San Francisco 49ers coach Kyle Shanahan's offense.

Matt Maiocco hands out team grades from the San Francisco 49ers' Week 16 win over the Indianapolis Colts on Monday at Lucas Oil Stadium.

The Seahawks claimed the No. 1 seed in the NFC after defeating the 49ers in Week 18. USA TODAY Sports provided updates, highlights, stats and more.

Will the Chicago Bears defeat the San Francisco 49ers in prime time? We make our Week 17 picks and predictions.

The 49ers face the Seahawks for the NFC West title and the No. 1 seed on Sunday and Trent Williams' health could prove pivotal.

See who's in and who's out for the Week 17 matchup between the San Francisco 49ers and Chicago Bears on December 28, 2025.

The Chicago Bears will face the San Francisco 49ers on Sunday Night Football. This is why they will or won't win the game.

The No. 1 seed in the NFC is up for grabs on Saturday night, as the Seattle Seahawks hit the road to play the San Francisco 49ers.  The winner of this game will

The Seahawks traveled to Santa Clara for a Week 18 divisional showdown vs. the 49ers for the NFC West crown and the conference's top seed. Relive how Seattle defeated their division rival to close out the regular season.

The San Francisco 49ers take on the Philadelphia Eagles this Sunday in the playoffs as the Bay Area gears up to host the Super Bowl. Why it matters: Largely seen as an underdog, the Niners are trying to extend a season that defied expectations despite a rotating door of injuries.