The ~30 proteins of the complement system cooperate to make a vital contribution to innate immunity 1. The complement system is important for clearing immune complexes and cellular debris and for ...

Panel A shows the profile of autoantibodies binding to factor B, C3b, and C3 activation fragments in Patients 1 and 2. I bars denote the standard deviation of three independent tests. As shown in ...

Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is ...

The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...

In this analysis of patients with myeloperoxidase-ANCA-positive AAV, all urinary complement C3 fragment levels were elevated significantly compared with healthy controls (P <.01 for all).

Among people with sickle cell disease—an inherited blood disorder—acute chest syndrome (ACS) is the leading cause of death. The condition is the result of red blood cells becoming stiff, sticky, and ...