The cerebral cortex, the brain's outermost region responsible for higher cognitive functions, depends on a highly ordered, layered structure. Its proper development requires newly generated neurons to ...

Researchers discover that the RNA surveillance system NMD and the protein UPF2 are essential for guiding neuronal migration and forming the brain's layered cortex.

Perhaps our most defining characteristic as a species, the six-layered human cortex, hosts billions of neural connections that bestow Homo sapiens with higher-order thinking. But how does this ...

Researchers found that nonsense-mediated mRNA decay, via the UPF2 protein, is crucial for neuronal migration and cortical ...

“It is an outstanding example of circuit analysis and a real experimental tour de force,” said neuroscientist Massimo Scanziani of the University of California, San Diego, who was not involved in the ...

The trial-to-trial variability of neuronal responses and the correlated response variability among neurons are modulated by visual stimulus size in a manner that depends on cortical layer, suggesting ...

Scientists have spent decades trying to understand whether the layered sheet of tissue that covers your brain follows one common pattern for handling information. Each region of the cortex contains ...

A new study finds key differences in the development of the cortex between autistic boys and girls ages 2-13. The study found sex-specific changes in the thickness of the outer layer of the brain, ...

For more than 50 years, it has been known that in the cerebral cortex of many mammals, neurons with the same function are grouped into columns. Now, for the first time, researchers at the Max Planck ...

What goes wrong first in the Alzheimer’s disease brain? Scientists led by Marc Aurel Busche of the U.K. Dementia Research Institute at University College London may have an answer. In the May 7 Neuron ...