Adam Schefter shared updates on Trent Williams’ hamstring and George Kittle’s ankle ahead of 49ers-Seahawks on Saturday night with the No. 1 seed at stake.

Saturday night celebrates the Faithful as the 49ers host the Seattle Seahawks in primetime for the final regular-season game. The NFC West crown and the No. 1 seed are on the line.

With the No. 1 seed on the line against the Seahawks, 49ers offensive lineman Trent Williams might not play, but another could step up.

NFL Week 18 odds, picks, predictions, TV channel, streaming information for Saturday football game between Seattle Seahawks and San Francisco 49ers.

The San Francisco 49ers could be without two star players against the Seattle Seahawks in a pivotal Week 18 showdown.

Watch the NFL's official Week 18 game preview for Seattle Seahawks vs. San Francisco 49ers. Go on the field with the San Francisco 49ers players during the team's 42-38 victory over the Chicago Bears. Watch the NFL's official Week 18 game preview for Seattle Seahawks vs. San Francisco 49ers.

Seattle presents many challenges, but one of the most difficult matchups is with wide receiver Jaxon Smith-Njigba, who isn’t a household name yet in his third year out of Ohio State but probably should be. The Seahawks felt good enough about him to trade D.K. Metcalf, their No. 1 receiver, to Pittsburgh in the offseason.

Seattle Seahawks' general manager John Schneider gets an A+ for a 2025 draft class led by Grey Zabel and Nick Emmanwori.