In intensified bioprocessing, the engineered CHO host supports higher titers and long culture duration in continuous ...

Large molecule biotherapeutics are primarily expressed and produced in mammalian host cells then purified from complex mixtures containing growth media and host cell material. Identifying, monitoring, ...

Host cell protein (HCP) analysis remains a pivotal aspect in the development and manufacture of biopharmaceuticals, ensuring that therapeutic products meet stringent quality and safety standards. HCPs ...

The endoplasmic reticulum (ER) is a crucial organelle present in eukaryotic cells, including human cells. The ER plays a vital part in making sure proteins are properly constructed, and that they get ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including Mycobacterium tuberculosis (Mtb), which causes tuberculosis featuring lung ...

Bacteria that cause diseases, so-called pathogens, develop various strategies to exploit human cells as hosts to their own advantage. Researchers have now uncovered the attack strategies employed by ...

Genes in the nucleus of the host cell have now replaced their functions. Nowack: "These fundamental findings help us understand how an organelle evolves from a bacterium. Using this mechanism, it may ...

The cold season is in full swing, throats are scratchy and noses are running. We feel ill and hope it is not the flu. The ...

For over three decades, HIV has played an elaborate game of hide-and-seek with researchers, making treating—and possibly even curing—the disease a seemingly insurmountable obstacle to achieve. But ...

Addressing subject matter eligibility in the life sciences context, the US Court of Appeals for the Federal Circuit reversed a district court’s summary judgment ruling that certain claims directed to ...

A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...