Antibodies are Y-shaped protective proteins manufactured by B lymphocytes in reaction to invading pathogens. When B lymphocytes encounter foreign antigens expressed by antigen-presenting cells (e.g.

The history of antibody engineering and production in drug discovery can be traced back to the 1970s and 1980s [1] when scientists first began to explore the potential of using antibodies as ...

In the past few years, multispecific antibodies, such as trispecific, bispecific, and tetraspecific, have become popular in antibody therapeutics. Compared to conventional monospecific antibodies, ...

In therapeutic applications, monoclonal antibodies (mAbs) provide highly precise targeting of pathological cells and reduced side effects in treating disease. Experimental mice are widely used models ...

A first-in-human study of AO-176, a highly differentiated anti-CD47 antibody, in patients with advanced solid tumors. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This ...

FOLFIRINOX versus sequential 5-FU, oxaliplatin, and irinotecan-based regimens in patients with recurrent pancreatic cancer (rPDAC). This is an ASCO Meeting Abstract from the 2020 ASCO Annual Meeting I ...

ORLANDO, Fla., April 5, 2011 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the ...

Researchers have developed an antibody that prevents the activation of the Dickkopf 1-Cytoskeleton-associated protein 4 (DKK1-CKAP4) pathway, which is important for tumor growth in several cancers, ...

Mucormycosis, a fungal infection caused by Mucorales, has high mortality rates in people with weakened immune systems and those suffering from severe trauma like burns, blast injuries or victims of ...

Antibody engineering and production are essential tools in drug discovery, providing powerful and specific therapeutics and diagnostic/prognostic materials for various diseases. Antibodies are ...