IL-4 and IL-13 act on human lung fibroblasts through specific receptors differing in their composition. Indeed, the γc chain is constitutively expressed in tumor lung myofibroblast but not in normal ...
Dupilumab is a human monoclonal antibody that blocks interleukin-4 and interleukin-13 pathways and has shown efficacy in five different atopic diseases marked by type 2 inflammation, including ...
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