Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 24 (June 16, 2020), pp. 13437-13446 (10 pages) Pentameric ligand-gated ion channels (pLGICs) are ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.

Researchers at Case Western Reserve University had an article titled “Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel” published in ...

Arthur Brown, M.D., Ph.D., president and CEO of ChanTest, summed up the sentiments of a number of speakers at the recent “SBS Conference” in Lille, France, when he said, “Ion channels are as abundant ...

For the first time, researchers identified the function of the CASKIN2 protein, which plays a key role in precise signal transmission between neurons and memory formation in the brain. This study is ...

More is not necessarily better, as was previously examined in an article about the pitfalls of high-throughput screening (GEN, March 15, 2006, pg. 24), not the least of which is the terabytes of ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Leucine-rich repeats containing 4 (LRRC4)—a gene abundantly found in the brain and located on human chromosome 7q31–32—plays a pivotal role in memory formation, autism, spinal cord injury, as well as ...