Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Add Yahoo as a preferred source to see more of our stories on Google. Naloxone competes with opioids for the same receptor on the surface of neurons. Matt Rourke/AP Photo Naloxone, also known by the ...

While opioid-based therapies remain important in clinical practice, adverse effects and addiction risks highlight an urgent need for alternative analgesics. This requires new molecular mechanisms ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Epidermal growth factor receptor (EGFR) signaling in the tissue around oral cancers both increases nerve sensitivity and makes opioids less effective. The findings point to a shared mechanism ...

Opioid dependence, characterized by high relapse rates and substantial social harm, represents a major global public health ...