Effect of body position on ventricular CSF methotrexate concentration following intralumbar administration. Paclitaxel pharmacokinetics were studied in 55 courses of therapy in 30 patients. Paclitaxel ...
Idarubicin cardiotoxicity: a retrospective study in acute myeloid leukemia and myelodysplasia. Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified ...
Mycophenolate mofetil (MMF, CellCept ®; Roche Laboratories, Nutley, NJ, USA) has been widely accepted as the antimetabolite immunosuppressant of choice in the immunosuppressive regimen of solid organ ...
The pharmacokinetics, safety, and tolerability of four topical lidocaine patches 5% continuously applied for 72 hours and changed every 12 or 24 hours were examined. In this randomized, prospective, ...
“Start low, go slow.” Geriatric pharmacology texts and recent systematic reviews (e.g., on dosing of oncology drugs) warn ...
ADME is the abbreviation for absorption, distribution, metabolism and excretion. ADME studies are designed to investigate how a chemical (e.g., a drug compound) is processed by a living organism.
Vincristine, one of the naturally occurring vinca alkaloids extracted from the leaves of the periwinkle plant Catharanthus roseus, continues to play a key role in the treatment of childhood ALL since ...
Irrespective of what therapeutic area or drug target a discovery program pursues, a common bottleneck that cannot be avoided is pharmacokinetics and safety. Thus, all drugs must enter the body, ...
The NMR and Drug Metabolism Core has developed rapid and efficient approaches to investigate metabolism, metabolic stability, pharmacokinetics (PK), and chemical structure identification of small ...
Discovering and bringing a new drug to market typically takes 14 years and costs approximately $ 2 billion USD. Today, the competitive landscape throughout the drug development process requires ...
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