College football Week 12 score predictions, picks for every Big 12 game, including West Virginia-Arizona State, TCU-BYU, Kansas State-Oklahoma State.

College football Week 12 betting spreads, lines, point totals for every game on Big 12 schedule, with odds for favorites, underdogs in each matchup.

TCU football remains alive in the Big 12 title race, but the betting odds reflect just how steep of a hill the Horned Frogs have to climb. TCU is 22-1 at DraftKings sportsbook, which translates to a 4.3% chance to prevail in the Big 12 championship game Dec. 6 at AT&T Stadium in Arlington.

BYU is no longer undefeated. However, the Cougars still control their own destiny to the Big 12 title game. If BYU wins out, they will be in regardless of what

Spread favorite: TCU (-6.5) Against the spread, TCU is 4-3-1 this year. TCU has two wins ATS (2-2) as a 6.5-point or higher favorite in 2025. Out of eight TCU games so far this season, four have hit the over. Iowa State's record against the spread in 2025 is 3-5-1.

Arlington Lamar standout Khamill Pruitt committed to the Horned Frogs, becoming the 19th commitment for the Class of 2026