The skeleton undergoes continuous remodeling throughout life in response to diverse environmental stimuli. Osteoclasts, which are specialized cells on the bone surface, break down old bone tissue (in ...

Researchers of Osaka University have discovered a way to visualize sites where bone-resorbing cells (osteoclasts) were in the process of resorbing bone in living mice. This real-time visualization of ...

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

Researchers have discovered a way to visualize sites where bone-resorbing cells (osteoclasts) were in the process of resorbing bone in living mice. This real-time visualization of changes in ...

Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...

A new discovery about osteoporosis suggests a potential treatment target for that brittle-bone disease and for bone loss from rheumatoid arthritis. The findings from University of Virginia School of ...

The number of Americans stricken by a deadly and debilitating bone-thinning disease continues to climb. According to a 2004 Surgeon General's report, more than half of Americans age 50 and older are ...

Throughout our lives, our bones are continuously remodeled to maintain strength, repair injuries and adapt to new stresses. Bone dynamics depend on two associated cell types: osteoblasts, which are ...

A new discovery about osteoporosis suggests a potential treatment target for that brittle-bone disease and for bone loss from rheumatoid arthritis. The findings from University of Virginia School of ...

A new discovery about osteoporosis suggests a potential treatment target for that brittle-bone disease and for bone loss from rheumatoid arthritis. A new discovery about osteoporosis suggests a ...