Growing from a single cell into a complex organism with specialized tissues and organs requires a complex and coordinated process. But the mechanical signals that guide tissue and organ ...

For in vitro cellular assays, the extracellular matrix—the material between cells—often is overlooked, but changes within this microenvironment affect cells’ proliferation and differentiation and, ...

Recently, a research team from Chongqing Medical University, led by Prof. Wei Huang, Dr. Wei Bao, and Dr. Yiting Lei, has successfully developed a novel engineered extracellular matrix (eECM) to ...

Scientists have developed a synthetic extracellular matrix (ECM) that can support the growth of a mini endometrium in a dish for at least two weeks. The endometrium—the mucosal lining of the ...

Cartilage injuries are a common clinical issue, often caused by trauma, severe infections, or degenerative joint diseases. The lack of direct blood supply to cartilage and limited access to nutrients ...

Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered a specialized population of neutrophils in the skin that produce extracellular matrix components, helping ...

Amyotrophic lateral sclerosis and frontotemporal dementia are heterogeneous diseases that are difficult to fully model in mice. One of the more common forms is caused by hexanucleotide repeat ...

Researchers at the Graduate School of Medicine, Kyoto University have successfully grown patient-derived colorectal cancer cells in three-dimensional culture using MatriMix 511, a fully defined ...

Biofilm-resident bacteria and fungi are significantly more tolerant to conventional antibiotics. The extracellular polymeric substance matrix acts as a ...