Recent changes in U.S. vaccine policy are sowing confusion and threatening the health of children and the wider population. How should pediatric clinicians communicate with parents to stem the damage?

Medical evidence comes in the form of population statistics, but patients behave like people, each one unique. Physicians walk the line, studying bell curves but hoping each intervention has an ...

Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Some foreign pharmaceutical plants that export generic drugs to the United States have glaring quality problems that can lead to drug shortages. There is a better way to assure the safety of ...

A 69-year-old man presented with a history of gradual thickening and wrinkling of the skin on the left side of his face. The physical examination showed hyperkeratosis with accentuated ridging, ...

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

European Study of Prostate Cancer Screening — 23-Year Follow-up (N Engl J Med 2025;393:1669-1680). In the “Additional Analysis” subsection of Results (page 1673), the first sentence of the second p ...

As a legacy of African enslavement, structural racism affects both population and individual health in three interrelated domains: redlining and racialized residential segregation, mass incarceration ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 3).

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 5).

A 44-year-old woman with recurrent oral aphthous ulcers presented with a progressively worsening papulopustular rash on her face and legs. Skin biopsy of a leg lesion revealed focal small-vessel va ...