Amid growing concerns about the poor design of animal experiments and its implications for the translatability of experimental results, Michael F. W. Festing thinks it's time we do something about it.

In research, the results of studies must be precise and reproducible. For this reason, researchers carried out experiments under strictly standardized laboratory conditions. However, despite the high ...

The justification of sample size is one of the hardest sections of a proposal an IACUC (ethical review board) has to assess, yet is arguably one of the most important (1). This is a key opportunity ...

Preclinical model systems are invaluable tools for drug discovery and development. But many complex diseases, such as nonalcoholic steatohepatitis (NASH), are difficult to recapitulate in the ...

One of the hottest debates in evolutionary biology concerns the origin of behavior: is it genetically encoded or do animals and birds copy their parents or other individuals? A classic experiment ...

Quantum designers: Florian Marquardt (left) and Leopoldo Sarra have shown how deep Bayesian experimental design can be applied to quantum many-body systems. (Courtesy: Leopoldo Sarra) As quantum ...

In this module, we will introduce the basic conceptual framework for experimental design and define the models that will allow us to answer meaningful questions about the differences between group ...

Introduction / Erik J. Marsh and Jeffrey R. Ferguson -- Understanding ceramic manufacturing technology : the role of experimental archaeology / Karen G. Harry -- Ceramic vessel use and use alteration ...

The rapid expansion of large language models' (LLMs) capabilities—including web search, code execution, data analysis and ...