Get the opening NFL Week 10 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Nov. 6, 2025.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 9 on a sizzling 45-28 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The Sunday afternoon slate for Week 9 is headlined by two big AFC matchups with playoff implications. In the early afternoon window, it's two first-place teams facing off when the Indianapolis Colts (7-1) head to Pittsburgh (4-3) for a showdown with the Steelers.

Now that most of the NFL Week 9 schedule is in the books, it is time to take a look at some of the biggest winners and losers around the NFL. There were big upsets, big comebacks and some big performances that stood out in both positive and negative ways.

The Indianapolis Colts entered Week 9 as the AFC's No. 1 seed and the NFL's most explosive offense. Daniel Jones looked reborn, playing like one of the league's most efficient quarterbacks. And then it all came crashing down in Pittsburgh.

Here's looking at the 14 teams that would be in the playoffs if the 2025 NFL season ended ahead of Week 10, from top seeds to final wild cards in both conferences.

The Indianapolis Colts lose to the AFC North leading Pittsburgh Steelers: Game results, highlights in NFL Week 9 action.