Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.

Sensory Stimulation Systems, and GENUS, refer to a noninvasive procedure, i.e., a "digital therapeutic," being developed by Cognito Therapeutics. The company developed a wearable GammaSense ...

Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser ...

Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...

Massage might help your brain flow regain its mojo. On June 4 in Nature, researchers led by Gou Young Koh at the Institute for Basic Science in Daejeon, South Korea, mapped the labyrinth of lymphatics ...

To narrow down the number of scents needed for such a test, Li first ranked each of the 16 SST-ID and 40 UPSIT scents for their ability to distinguish PD/DLB from controls in three cohorts—the De Novo ...

Since February, the termination of some 2,482 grants worth $8.6 billion has shaken the scientific community, including AD researchers. Thanks to government databases and intrepid scientists tracking ...

A robust immune response to viral infections may protect against more than just a runny nose or a cold sore—it might also stave off Alzheimer’s disease. In the May 30 Science Advances, scientists led ...

A cadre of T cells, originating in gut and fat tissue, resides in the brain. The cells sit in the subfornical organ, which surveils the blood. They affect food-seeking behavior by releasing interferon ...

Certain brain regions of healthy old mice and humans harbor monocyte-derived microglia. The transcriptome of some monocyte-derived microglia was identical to that of yolk sac-derived microglia.

Prior data hinted that taurine levels decrease with age. Now, longitudinal data show taurine remains stable, or even increases. The nonessential amino acid is no marker of aging.