ETX-19477 is a potent, selective inhibitor of poly (ADP-ribose) glycohydrolase (PARG), an enzyme that plays a role in the DNA ...

Switching to a second TNF inhibitor in inflammatory bowel disease may raise the risk for immune-mediated inflammatory ...

Exposure to TNF inhibitors during pregnancy and postpartum was not associated with a significantly increased risk for serious infection.

In the CAPItello-291 trial of capivasertib plus fulvestrant, 73% of patients had already received a CDK4/6 inhibitor. As compared with fulvestrant alone, the combination more than doubled the median ...

Zoldonrasib is an innovative tri-complex inhibitor that binds to cyclophilin A, creating a complex that selectively recognizes and inhibits the active, oncogenic RAS G12D (ON) mutant. Revolution ...

The new Phase III study will test calderasib in a chemo-free regimen for G12C-mutated patients regardless of PD-L1 status.

Abstract Aromatase inhibitor–induced musculoskeletal symptoms (AIMSS) were first recognized as a distinct entity in 2001, 5 years after the approval of the first aromatase inhibitor, anastrozole.

Immune checkpoint molecules play a crucial role in keeping the immune system in balance and preventing an attack on the ...

Of course, they’ll help manage high blood pressure. But your doctor may prescribe an ACE inhibitor for these other heart conditions: Heart failure: They can prevent further weakening of your heart and ...

SGLT2 inhibitors are one of many medicines you may take to treat type 2 diabetes. They also can protect your kidneys and make heart failure less likely. (Photo Credit: Moment RF/Getty Images) SGLT2 ...

Cryogenic electron microscopy models of inflammasome rings (center, ring with hooks) and gasdermin pores (bottom right) Cryogenic electron microscopy models of inflammasome rings (center, ring with ...