Various humoral factors are involved in the physiological and pathological conditions in both vascular and metabolic system. Adrenomedullin (AM), originally identified as a vasodilatory peptide, is ...

Background: It has been shown that tumor-associated immune cells, particularly macrophages, play a fundamental role in the development and treatment response of intrahepatic cholangiocarcinoma (ICC).

RAMP2-AS1 and CXCL11 expression in breast cancer tissues and cells were determined using RT-qPCR or Western blot. RIP analysis confirmed the interaction between DNMT1, DNMT3B and RAMP2-AS1. ChIP assay ...

G protein–coupled receptors (GPCRs) constitute the largest and pharmacologically most important family of cell-surface receptors. Some GPCRs interact specifically with receptor-activity-modifying ...

We thank all members of the M.J.L. laboratory, especially Ali Isbilir and Jan Möller, for valuable discussions on the manuscript. G.K. and P.S. were supported by the DFG - German Research Foundation ...

Figure 1 shows the overall flowchart of our in silico assessments. To better comprehend the underlying biological processes and pathways, disease ontology (DO), functional enrichment of gene ontology ...

Researchers suggest that the retinoprotectivity of the ADM-RAMP2 system makes it an ideal therapeutic target for central retinal vein occlusion (CRVO)… A model of central retinal vein occlusion (CRVO) ...

A model of central retinal vein occlusion that mimics many of its clinical features has been developed to test new therapies using ADM-RAMP2 for this common form of visual impairment, according to a ...

A clot in the retinal vein can lead to severe and irreversible loss of vision. In a report in the American Journal of Pathology investigators utilize a newly developed model of central retinal vein ...