BMJ

Rituximab for IgG4-related disease: a prospective, open-label trial

Objectives To evaluate the efficacy of rituximab (RTX) in IgG4-related disease (IgG4-RD) in an open-label pilot trial. Methods We treated 30 IgG4-RD patients with two doses of RTX (1000 mg each). The ...
BMJ

Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data ...

Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an ...
BMJ

International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies

16 Department of Clinical Microbiology, Clinical Immunology, Umeå University, Umeå, Sweden 17 Department of Laboratory Medicine, Clinical Immunology, University Hospital of Orebro and Orebro ...
BMJ

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Objective Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, ...
BMJ

A disease activity score for polymyalgia rheumatica

Objective: To develop a composite score for measurement of disease activity in polymyalgia rheumatica (PMR) and assess its internal and external validity. Methods: A PMR activity score (AS) was ...
BMJ

Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis

8 University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany Correspondence to Professor Koen Venken, Department of Internal Medicine and Pediatrics (Rheumatology Unit), ...
BMJ

Ankylosing spondylitis: an overview

1 Department of Gastroenterology and Rheumatology, Free University, Berlin, Germany 2 Rheumazentrum Ruhrgebiet, Herne, Germany and Department of Gastroenterology and Rheumatology, Free University, ...
BMJ

Long-term outcome in polymyositis and dermatomyositis

1 Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands 2 Department of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands ...
BMJ

Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: a randomised, double-blinded, sham-controlled trial

Correspondence to Elien A M Mahler, Department of Rheumatology, Sint Maartenskliniek Nijmegen, Nijmegen 90116500, The Netherlands; e.mahler{at}maartenskliniek.nl Objectives Low-dose radiation therapy ...
BMJ

Assessment of outcome in ankylosing spondylitis: an extended radiographic scoring system

1 Department of Rheumatology, University Medical Centre St Radboud, Nijmegen, The Netherlands 2 Department of Rheumatology, St Maartenshospital, Nijmegen, The Netherlands 3 Department of Medical ...
BMJ

POS0664 PREDICTORS OF RHEUMATOID ARTHRITIS DEVELOPMENT IN AT-RISK INDIVIDUALS; A FIVE-YEAR FOLLOW-UP STUDY IN A LARGE PRACTICE-BASED COHORT

1 Amsterdam University Medical Center, University of Amsterdam, Department of Rheumatology and Clinical Immunology, Amsterdam, Netherlands 2 Amsterdam Rheumatology and Immunology Center, Amsterdam, ...
BMJ

Preliminary results of early clinical trials with the fully human anti-TNFα monoclonal antibody D2E7

Department of Clinical Oncology/Immunology, Knoll AG-BASF Pharma, Knollstrasse, D-67008 Ludwigshafen, Germany Dr J Kempeni.