Medical evidence comes in the form of population statistics, but patients behave like people, each one unique. Physicians walk the line, studying bell curves but hoping each intervention has an ...

States have responded to increasing health care consolidation by enhancing their review of mergers and acquisitions. But some states have carved out certain academic medical centers from such ...

Some foreign pharmaceutical plants that export generic drugs to the United States have glaring quality problems that can lead to drug shortages. There is a better way to assure the safety of ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic ...

European Study of Prostate Cancer Screening — 23-Year Follow-up (N Engl J Med 2025;393:1669-1680). In the “Additional Analysis” subsection of Results (page 1673), the first sentence of the second p ...

Faced with a young woman whose seizures, of untraceable cause, can’t be stopped by the medical team, a medical student viscerally learns the limits to what can be accomplished by pushing harder.

Trainees’ paths to safe, independent practice are variable. Artificial intelligence could help accelerate implementation of competency-based medical education to support individualized development.

Popeye Sign in Transthyretin Amyloidosis (Images in Clinical Medicine, N Engl J Med 2025;393:906-906). In the fourth sentence, beginning “This finding — known as the Popeye sign,” biceps tendon ...

Recent FDA actions related to leucovorin have caused confusion. There is still a lack of scientific evidence establishing that the drug is a safe and effective treatment for autism.

Today, medical research builds up an understanding of the whole from molecular parts, but artificial intelligence can revive an approach building down from patient-level data to theory and understa ...

Corporatization exacerbates the problem of perverse incentives for health care organizations, pitting profits against health maintenance. How could delivering health become a sustainable business?